RA Synovium NET Shooter
Wave 1
Neutrophil health
100
Inflammation
25
NET tissue damage
0
Cleared: 0 Stabilise: 02:30
WASD / arrows move Mouse or Space fires NETs
NET Targets
Immune complexesGlowing antibody-antigen clusters
Platelets / microthrombiOrange discs, raise NET burden
Citrullinated debrisYellow autoantigen fragments
Cytokine cloudsPink TNF / IL-6 / IL-1 signals
Invasive synoviocytesPurple crawling stromal cells
Complement burstsCyan hazards that damage health